Speakers > Colette Dehay
Stem cell and Brain Research Institute ( SBRI ) Lyon, France
My research has largely addressed specific features of primate cortical development. This concerns the intrinsic specification of cortical areas and how extrinsic factors such as thalamic afferents can shape the dynamics of neuron production. A major finding is that the germinal zone of the primate has unique features which are highly specialized for the production of the supragranular layers. I have a long-standing interest in the distinctive features of the primate upper-layers neurons and their involvement in the hierarchical organization of the adult cortex.
The role of OSVZ in shaping the primate visual cortex architecture
The study of the cellular and molecular mechanisms controling corticogenesis in the primate visual system highlight the dual pillar role of the primate-specific germinal zone: the OSVZ in the establishment of area-specific cytoarchitectural features. The OSVZ is responsible for (i) generating area-specific numbers of SG neurons with increased diversity and (ii) providing an area-specific scaffolding that is constraining the properties and dynamics of postmitotic radial migration. Together our work points to the OSVZ as a unique machinery to build the primate cortex and its connectivity. |
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